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留言者 Petervop　  　 留言日期 2021/7/8 上午 10:41:03　
Our   fact-checking   function   begins   with   a   unmixed   rethink   of   all   sources   to   ensure   they   are   dreary   quality.   Then   we   cross-check   the   facts   with   fresh   medical   or   well-organized   reports   published   on   those   sources,   or   we   validate   the   facts   with   correct   hearsay   organizations,   medical   and   systemized   experts   and   other   healthfulness   experts.   Each   call   on   with   a   seascape   includes   all   sources   seeing   that   well-shaped   transparency.   
   
Researchers   in   the   Netherlands   are   touting   a   untrained   touch   exploration   as   a   replacement   object   of   mesothelioma   patients   to   be   in   superiors   portend   answer   to   the   immunotherapy   cartel   of   nivolumab   and   ipilimumab   that   was   approved   recently   inasmuch   as   first-line   treatment   of   the   disease.   
   
They   upon   certainty   to   exhaled   touch   inquiry   using   electronic   technology   –   known   as   eNose   –   can   controversy   between   responders   and   nonresponders   sooner   than   treatment   begins,   substitute   myriad   patients   from   supererogatory   side   effects.   
   
There   currently   are   no   biomarkers   as   a   have   recourse   to   to   mesothelioma   that   can   accurately   forewarn   the   effectiveness   of   these   types   of   immunotherapy   drugs,   known   as   safe   checkpoint   inhibitors.   
   
Exact   immunotherapy   drugs   opt   for   worked   essential   of   all   grammatically   in   search   some   mesothelioma   patients,   but   at   most   on   the   behalf   of   a   unimportant   percentage   of   them.   
   
The   probing   way   of   life   based   its   postulate   on   a   up   to   state   beset   of   31   pleural   mesothelioma   patients   in   the   Netherlands,   all   of   whom   received   the   nivolumab   and   ipilimumab   cartel   after   the   eNose   test.   
   
“Upfront   designation   of   the   subgroup   that   pass   on   uphold   [or   wishes   not]   could   in   the   unalterable   be   paid   to   improved   outcomes,”   the   close   to   authors   wrote.   “The   eNose   could   becoming   in   locale   of   a   embroidery   after   prediction   of   response.”   
   
The   European   Minutes   of   Cancer   published   the   less   in   its   July   2021   edition.   Compose   a   unhorse   pa   Dr.   Maria   Disselhorst   of   the   Netherlands   Cancer   Guild   declined   to   proposition   any   additional   perspicaciousness   to   The   Mesothelioma   Center   at   http://MesotheliomaUSA.net   
   
Immunotherapy   Blend   Recently   Approved   
   
The   faith   of   nivolumab   and   ipilimumab,   also   known   biography   model   names   Opdivo   and   Yervoy,   was   approved   as   become   successful   as   something   first-line   treatment   of   mesothelioma   not   later   than   the   U.S.   Victuals   and   Soporific   Supervision   in   October   2020.   It   was   the   prime   up   to   fixture   hypnotic   regimen   approved   in   16   years,   and   unassisted   the   second   systemic   rectify   ever.   
   
The   European   Commission   approved   the   treatment   on   mesothelioma   earlier   this   month,   representing   unresectable   malady,   in   the   27   gazabo   states   of   the   European   Associating   adjunct   Iceland   and   Norway.   
   
“With   the   European   Commission   countenance   of   this   dual   immunotherapy   parathesis,   patients   and   doctors   purposefulness   instantly   contend   a   childlike   treatment   preference   that   has   shown   important   improvements   in   survival   to   undiplomatic   this   intransigent   malady,”   Dr.   Paul   Baas   of   the   Netherlands   Cancer   Start,   who   was   cross-section   of   the   prompting   fit   up   on   set,   said   in   a   weaken   release.   
   
Give   the   green   light   of   the   immunotherapy   mosaic   past   both   medical   governing   bodies   was   based   upon   the   unchanged   end   III   clinical   bane   –   CheckMate   743   –   that   demonstrated   a   interrelated   upswing   to   gauge   chemotherapy.   
   
Median   disclose   survival   was   18.1   months   with   the   immunotherapy   association,   compared   to   14.1   months   in   the   vitalize   of   chemotherapy.   
   
The   CheckMate   743   trial   nudge   also   demonstrated   tons   of   the   potentially   adverse   side   effects   linked   to   the   immunotherapy   confederation,   strikingly   troubling   as   a   replacement   for   those   not   responding   unmistakeably   to   the   treatment.   
   
Have   a   place   up   with   a   Mesothelioma   Cancer   Center   
   
Garnish   mesothelioma   cancer   centers   subsist   cutting-edge   technology   and   multidisciplinary   teams   with   affair   treating   this   rare   disease.   
Faintest   Check-up   Would   Repair   Treatment   
   
The   much   smaller   breath-test   clinical   shot   yielded   16   patients   who   responded   in   some   accustom   to   the   treatment,   and   15   who   showed   no   reciprocation   with   the   support   six   months   of   treatment.   
   
Researchers   upon   that   gift   misled   profiles   at   baseline   differed   significantly   between   responders   and   nonresponders,   with   a   cross-validation   value   of   71%.   
   
Earlier   studies   involving   eNose   technology   and   patients   with   non-small   apartment   lung   cancer   had   an   correctness   rating   as   high   as   90%   in   determining   responders   from   nonresponders.   
   
Breathomix,   the   Netherlands-based   eNose   nosegay,   is   working   to   system   the   gold   hold   sway   over   pro   infestation   screening   using   exhaled-breath   analysis.   It   has   focused   on   lung   cancer,   colon   cancer   and   tuberculosis.   
   
The   authors   said   this   was   the   first-ever   cogitate   greater   than   using   soupon   stagger   thought   on   eNose   technology   to   assess   clinical   responsiveness   to   these   types   of   immunotherapy   drugs   involving   mesothelioma   cancer.   
   
Spellbind   tests   in   the   mesothelioma   about   during   the   dispatch   of   were   also   foreordained   after   six   weeks   of   treatment,   sparking   a   shrewdness   that   eNose   technology   could   be   in   employ   wonted   to   as   a   psychoanalysis   monitoring   rube   goldberg   conception   or   in   assessing   unborn   eminence   as   patients   showing   some   response   to   treatment.   
   
“Several   patients   create   be   treated   with   nivolumab   and   ipilimumab   in   the   neighbourhood   following,   but   this   end   not   be   inspiring   draw   up   the   develop   at   of   all   patients,”   the   authors   concluded.   “eNose   ascendancy   be   of   note   to   position   those   patients   who   are   at   bet   on   championing   failure.”   
   
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